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However, neither myoblast- nor myofiber-specific ARKO impacted voluntary running wheel activity in 12-week-old male mice, even with the modest reductions in absolute and relative hindlimb muscle mass and elevations in WAT depot mass in those muscle-specific ARKO lines [183]
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doi: 10.3233/JAD-180584 239 TaiJLiuWLiYLiLHolscherC
Were giving your body time to adapt, and were identifying your therapeutic window where benefits are strong and side effects stay reasonable
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